My little brother likes cute little things, and I'm really thrilled to get him into anime, but it needs to be safe. My sister didn't know about Konata's porn habit when she started showing him Lucky Star, so I quickly warned her about it. See the problem?
I need some cute, clean shows that don't have much to do with religious/magical stuff. My parents are sensitive about that.
Also, it really doesn't matter if the show is a more typically "girly" show, since my little brother is the type of kid who likes anything sweet and innocent regardless of pastel coloring; I suppose his pre-cutoff enjoyment of Lucky Star illustrates that pretty well.
Boyish stuff is okay, too, but please no trading card based stuff. My parents believe Pokemon or anything similar is of the devil.